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影片讲述霍金卢伽雷氏症病情发作前的生活，主要关注点在霍金和他妻子之间的故事。由埃迪·雷德梅恩饰演霍金，而菲丽希缇·琼斯饰演他的首任夫人——简。影片从霍金的爱情生活切入，讲述性格内向、整日沉迷物理研究和瓦格纳歌剧的霍金在剑桥大学与简相遇、相恋的爱情故事。当21岁的霍金被查出患上会使四肢麻痹的卢伽伽雷氏症，只有2年的生命。当时的简并没有放弃他，而是想办法和他结婚，并陪伴他完成博士学业。

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